Biomedical Research
Research Award Programs
Funding great research begins with a focus on people and projects. Our Research Roadmap guides our work to address the critical knowledge gaps, advance discovery, and encourage collaboration within the single ventricle field and beyond.
We offer funding opportunities to support academic and clinical investigators to pursue relevant topics to single ventricle heart disease. Our programs aim to foster outstanding science across disciplines, fields, and career stages — and provide resources for our awardees to succeed.
Research Programs
OPEN
Expansion Award
Our Expansion Award enables teams to add new single ventricle–focused approaches and directions to their current work by providing a one-time grant of $50,000. This small but mighty grant is open to both new and established investigators within the single ventricle research community – and has a submission and award process that occurs in under two months’ time, spring-boarding these studies forward, faster.
Award Amount
Up to $50,000 for one year
Eligibility
Principal Investigator(s) (PIs) who hold doctoral degrees (e.g., PhD, MD, PsyD, or equivalent) and are listed as a PI on a parent grant.
CLOSED
Catalyst to Independence Award
Support for the next generation of scientists means investment in the future of the field.
The Additional Ventures Catalyst to Independence Award is a transition award that supports the next generation of researchers, catalyzing their careers and efforts to solve the biggest questions in single ventricle heart disease and related fields.
Award Amount
Up to $1.2M over up to 6 years
Eligibility
Applicants must have earned a PhD, MD, or doctoral equivalent more than 1 year prior to the application due date.
CLOSED
Single Ventricle Research Fund (SVRF)
The Single Ventricle Research Fund (SVRF) is an annual research award program that is solely focused on accelerating research and improving care for those with single ventricle heart defects through multi-year, high-impact grants. The SVRF grants awards annually to support research projects over up to three-year periods, and provides up to $600,000 in direct costs.
In its fourth cycle, the SVRF is hosting an open call, and welcomes any research with relevance to single ventricle. Resubmissions from previous cycles will also be accepted. This program opens June 1, 2023.
Award Amount
Up to $600,000 in direct costs to be utilized over three (3) years
Eligibility
Principal Investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates)
CLOSED
Life Sciences Research Foundation: Postdoctoral Fellowship
We believe in supporting the next generation of scientists. We partner with the Life Sciences Research Foundation to support outstanding postdoctoral fellows who are making waves in basic science and advancing fundamental knowledge. Interested fellows should apply through the LSRF website.
Award Amount
$67,000 per fellow per year for three (3) years
Eligibility
Applicants must apply within 5 years of receiving their PhD or MD degree
Funded Studies
Since 2020, we have committed over $23.5M in direct research support through our award programs. Our grant programs are changing the game by making big and bold investments in specific research questions. They are thoughtfully designed to reimagine the future by reexamining processes to maximize our impact on both people and projects.
ACTION: Advanced Cardiac Therapies Improving Outcomes Network
Investigator Angie Lorts
Organization ACTION
Focus Area Data & Analytics Infrastructure
Strategic Topic Harmonized Data & Analytics Platform
Back to the Future: Expanding Opportunities in Pediatric ABO-Incompatible Heart Transplantation
Investigator Lori West
Organization University of Alberta
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Ex situ heart perfusion for optimization of pediatric donor organ utilization: feasibility and methods
Investigator Darren Freed, Jennifer Conway
Organization Stollery Children's Hospital, University of Alberta
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Novel Approaches to Improve the Availability and/or the Quality of Pediatric Donor Hearts
Investigator James Reynolds
Organization Case Western Reserve University and University Hospitals
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Can HLA data be used to support Precision Medicine in Pediatric Heart Transplantation? An exploratory analysis
Investigator David Rosenthal
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
The impact of Fontan circulatory failure, frailty, and resilience on heart failure and transplant outcomes
Investigator Kurt Schumacher, Melissa Cousino
Organization University of Michigan
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Single-cell multi-omic profiling of the developing heart to map the regulatory wiring and identify the genetic etiology of single ventricle defects
Investigator Jesse Engreitz
Organization Stanford University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Expanded nucleotide sequencing for phenotypic mapping of cardiogenic neighborhoods
Investigator Jonathan Butcher
Organization Cornell University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Gene-environment interactions and single ventricle congenital heart disease
Investigator Duncan Sparrow
Organization University of Oxford
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Role of inflammation and flow in pulmonary arteriovenous malformations
Investigator Andrew Spearman
Organization The Medical College of Wisconsin
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Proteomics Analyses of Proteasome Factors in Zebrafish Heart Development
Investigator Lisa Maves
Organization Seattle Children’s Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Deep Learning and Physics Informed Neural Networks to Advance Single Ventricle Atrioventricular Valve Modeling
Investigator Matthew Jolley
Organization Children’s Hospital of Philadelphia
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Spatial Transcriptomics Investigation of Pediatric HLHS Myocardium
Investigator Diwakar Turaga
Organization Texas Children’s Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Precision Therapy for Endocardial Fibroelastosis
Investigator Ingeborg Friehs
Organization Boston Children’s Hospital
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics
Investigator Jian Shu
Organization Massachusetts General Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining cell specific roles of RBFOX2 in cardiovascular development and HLHS
Investigator Muge Kuyumcu-Martinez
Organization University of Texas Medical Branch at Galveston
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Predicting Cardiac Dysfunction and Fontan Failure in Single Ventricle Patients
Investigator Andrew McCulloch
Organization University of California, San Diego
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Combination proteomic and metabolic fingerprinting: a multi-omic approach to understanding longitudinal pulmonary vascular development in patients with single ventricle heart disease
Investigator Benjamin Frank, Jesse Davidson, & Michael DiMaria
Organization University of Colorado Denver/Children’s Hospital Colorado
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Deciphering the splicing code in cardiac progenitor cells
Investigator Susan Liao, Oded Regev
Organization New York University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
A pilot biorepository of patient-specific induced pluripotent stem cells for studying pulmonary atresia with intact ventricular septum
Investigator Mingtao Zhao, Vidu Garg, Karen Texter
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Characterization of exercise induced cardiac alterations in the Fontan Fitness Intervention Trial using cardiac MRI (F-FIT MRI Substudy)
Investigator Rachael Cordina
Organization University of Sydney
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Optimized metabolic biomarker detection for the development of heart failure diagnostic in single ventricle patients
Investigator Ronald Mark Payne, Thomas O'Connell
Organization Indiana University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Expanding the FORCE: Novel 3D Echocardiogram-Based Analysis of Ventricular Function in Single Ventricle Fontan Patients
Investigator David Harrild, Rahul Rathod
Organization Boston Children's Hospital
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
Novel Neuroimaging based Machine Learning Applications for Risk Stratification of Neurocognitive Deficits in HLHS Patients
Investigator Ashok Panigrahy, Rafael Ceschin
Organization University of Pittsburgh
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
“Single Ventricle Circulation”: Advancing a clinical decision support tool for single ventricle management
Investigator Richard Figliola, Tain-Yen Hsia
Organization Clemson University, Arnold Palmer Hospital for Children
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Analysis of Cellular Metabolic Function in Single Ventricle Heart Disease
Investigator Anastacia Garcia, Shelley Miyamoto
Organization University of Colorado Anschutz Medical Campus
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
FON: Fontan Outcomes Network
Investigator Jack Rychik and Sasha Opotowsky
Organization FON
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
FORCE: Fontan Outcomes Registry using CMR Examinations
Investigator Rahul Rathod
Organization Boston Children's Hospital
Focus Area Data & Analytics Infrastructure
Strategic Topic Longitudinal Clinical & Imaging Data
Elucidating mechanisms of ventricular hypoplasia in pulmonary atresia with intact ventricular septum (PA-IVS) using patient-derived induced pluripotent stem cells (iPSCs)
Investigator Mingtao Zhao, Vidu Garg
Organization Nationwide Children's Hospital
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Uncovering the etiology of hypoplastic left heart syndrome using a novel frog model
Investigator Shuyi Nie
Organization Coulter BME
Focus Area Disease Etiology
Strategic Topic Model Organism Development
Mapping the regulatory wiring of heart development to identify the genetic etiology of single ventricle defects
Investigator Jesse Engreitz
Organization Stanford
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Unlocking our Regenerative Capacity: Elucidating the Role of LYST on Neotissue Formation in Tissue Engineered Constructs
Investigator Richard Wilson, Christopher Breuer
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Ventricle chamber formation in mouse models of SV
Investigator Benoit Bruneau
Organization Gladstone Institutes
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
In-utero Left Ventricular Filling & Its Impact on Chamber Growth and Maturation: mechanistic insights into pathogenesis of HLHS and physiological basis for fetal interventions
Investigator Muralidhar Padala
Organization Coulter BME
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Using Audio Characteristics of Systemic to Pulmonary Connections in Functionally Single-Ventricle Infants as a Non-invasive Measure of Pulmonary Blood-flow Parameters
Investigator Saidie Rodriguez
Organization Coulter BME
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Development of a protocol to risk stratify individuals with single ventricle congenital heart disease using deep phenotyping and genome sequencing
Investigator Kim McBride, Peter White
Organization Nationwide Children's Hospital
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
Development of a tissue engineered trans-catheter heart valve for use in the endovascular repair of single ventricle cardiac anomalies in utero
Investigator Lakshmi Prasad Dasi
Organization Coulter BME
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
A 3D Printed Vascularized Cardiac Biopump to Assist the Fontan Circulation
Investigator Mark Skylar-Scott
Organization Stanford
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Reprogramming of Right Ventricle Cardiomyocytes to be Left Ventricular-lIke
Investigator Deepak Srivastava, Katie Pollard
Organization Gladstone Institutes
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Device for Mechanically Induced Ventricular Growth in Single Ventricle Patients
Investigator Alison Marsden
Organization Stanford
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Machine Learning-Based Boundary Conditions for Fontan Surgical Planning
Investigator David Frakes
Organization Coulter BME
Focus Area Clinical Sequelae
Strategic Topic Personalized Medicine Approaches
Lymphatic failure and genetic susceptibility; role in end-organ dysfunction in single ventricle patients
Investigator Yoav Dori, Daniel Licht, Hakon Hakonarson
Organization Children's Hospital of Philadelphia
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Origins and Burden of Multi-Organ Fibrosis in Patients with Single Ventricle Heart Disease
Investigator Elizabeth Goldmuntz, Jack Rychik
Organization Children's Hospital of Philadelphia
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Deciphering the Embryonic Stem Cell Splicing Code
Investigator Susan Liao
Organization NYU Courant Institute of Mathematical Sciences
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Engineering a self-deliverable CRISPR-Cas9 system for precise genome editing
Investigator Kai Chen
Organization University of California, Berkeley
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Cerebral Lower Limit of Autoregulation Targeted Mean Arterial Pressure Management in Neonates Undergoing Surgery for Single Ventricle Congenital Heart Disease
Investigator Bradley Marino, Kenneth Brady
Organization Ann & Robert H. Lurie Children’s Hospital of Chicago
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Precision Therapy for Endocardial Fibroelastosis
Investigator Lili Zhang
Organization Boston Children's Hospital
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Cerebrovascular Integrity in Fontan Patients
Investigator John Wood
Organization Children's Hospital of Los Angeles
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Blood Viscosity, a Critical Determinant of Pulmonary Vascular Resistance in the Fontan Circulation
Investigator Jon A. Detterich
Organization Children's Hospital of Los Angeles
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Transforming Mental Health Outcomes in Single Ventricle Heart Disease
Investigator Nadine Kasparian, James Cnota
Organization Cincinnati Children’s Hospital
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Enhanced External Counterpulsation in Patients with Fontan Circulation
Investigator Fred Wu
Organization Harvard Medical School
Focus Area Clinical Sequelae
Strategic Topic Alternative Interventions
Clinical Prediction Tool for Neurodevelopmental Outcome in Single Ventricle Heart Disease
Investigator Caitlin Rollins, Cynthia Ortinau
Organization Harvard Medical School, Washington University in St. Louis Medical School
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Development of a metabolic biomarker panel to identify SV patients at risk for heart failure
Investigator Ronald Mark Payne, Thomas O'Connell
Organization Indiana University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Nitric Oxide Pathway Biomarkers to Assess Prognosis and Individualize Care in Fontan Patients
Investigator Ari Cedars
Organization Johns Hopkins University
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
The Injection-Jet Powered Fontan Circulation: A Novel Bridge and Destination Therapy for the Failing Fontan
Investigator William DeCampli
Organization University of Central Florida
Focus Area Functional Cures
Strategic Topic Bionic, Regenerative, & Transplantation Approaches
Hippo/YAP signaling and genetic networks of HLHS
Investigator James Martin
Organization Baylor College of Medicine
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Transcriptional and morphogenetic signatures of congenital heart disease pathways
Investigator Alessandro Bertero
Organization Molecular Biotechnology Center, University of Turin
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Modeling human heart morphogenesis and congenital heart disease with bioreactor-derived cardiac organoids
Investigator William Pu
Organization Boston Children's Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Embryological origin of functional single ventricles in the heterotaxy syndrome
Investigator Sigolene Meilhac
Organization Institut Pasteur and Université de Paris
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Gene-regulatory impact of Wnt signaling in ventricle formation
Investigator Christian Mosimann
Organization University of Colorado School of Medicine, Anschutz Medical Campus
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Origin of Cardiac Pacemaker Cells
Investigator Vasanth Vedantham
Organization Cardiology Division and Cardiovascular Research Institute, University of California, San Francisco
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanisms of Left Ventricle Heart Development
Investigator Neil Chi
Organization University of California, San Diego
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining cell-specific roles of Rbfox2 in cardiovascular development
Investigator Muge Kuyumcu-Martinez
Organization University of Texas Medical Branch
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanisms of Early Ventricular Lineage Specification
Investigator Nicole Dubois
Organization Icahn School of Medicine at Mount Sinai
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mechanobiological mechanisms of cardiac morphogenesis
Investigator Stephanie Lindsey
Organization University of California, San Diego
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Mitochondrial citrate transport: A novel, potentially druggable link to hypoplastic right heart syndrome
Investigator Jennifer Kwong
Organization Emory University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Leveraging induced pluripotent stem cells to define the developmental drivers of hypoplastic left heart syndrome
Investigator Andrew Landstrom
Organization Duke University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Collective Neighborhood Signaling Driving Ventricular Growth, Maturation, and Pathogenesis
Investigator Jonathan Butcher
Organization Cornell University
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Gene-environment interactions and single ventricle congenital heart disease
Investigator Duncan Sparrow
Organization University of Oxford
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics
Investigator Jian Shu
Organization Massachusetts General Hospital
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
Defining Novel Roles for Proteasome Factors in Heart Development
Investigator Lisa Maves
Organization Seattle Children's Research Institute
Focus Area Disease Etiology
Strategic Topic Normal Cardiac Development
A reference map of enhancers during human fetal heart development to understand the genetic etiology of single ventricle diseases
Investigator Jesse Engreitz
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
A Multifaceted Approach to Understanding and Optimizing Single Ventricle Hemodynamics; Leveraging the Combined Power of In vitro Simulators, Computational Modeling and Clinical Imaging to Develop Non-Invasive Biomechanical Interventions.
Investigator Ellen Roche
Organization Massachusetts Institute of Technology
Focus Area Biology of Outcomes
Strategic Topic Predictive Models
Maternal Blood Biomarker Discovery for Predicting Ventricular Growth in Human Fetuses with PA-IVS
Investigator Mingtao Zhao
Organization Nationwide Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Early Detection
A Liquid Biopsy of myocardial signaling in children with single ventricle heart failure
Investigator Sushma Reddy
Organization Stanford University
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Targeting mitochondrial dysfunction to prevent heart failure in single ventricle congenital heart disease
Investigator Sharon Paige, Sean Wu, Tahmina Samad
Organization Stanford University School of Medicine
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Immunophenotyping in Pediatric Patients with Single Ventricle Congenital Heart Disease: Connecting Inflammatory and Immune Dysregulation with Outcomes
Investigator Stephanie Nakano
Organization University of Colorado Anschutz Medical Campus
Focus Area Biology of Outcomes
Strategic Topic Early Detection
Peripheral Mononuclear Cells as Biomarkers for Myocardial Metabolic Function in Single Ventricle Congenital Heart Disease Patients
Investigator Anastacia Garcia
Organization University of Colorado Anschutz Medical Campus
Focus Area Clinical Sequelae
Strategic Topic End Organ Trajectory Mapping & Biomarkers
Understanding and Reducing Sequelae Associated with Single Ventricle Physiology
Investigator Jay Humphrey, Edward Manning
Organization Yale University
Focus Area Biology of Outcomes
Strategic Topic Substrate-Outcome Relationships
Functional Characterization of Patient-Specific Pathogenic Variants in Single Ventricle Congenital Heart Disease
Investigator Daniel Quiat
Organization Boston Children's Hospital
Focus Area Biology of Outcomes
Strategic Topic Outcome Origins
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