Funding great research begins with a focus on people and projects. Our Research Roadmap guides our work to address the critical knowledge gaps, advance discovery, and encourage collaboration within the single ventricle field and beyond.

We offer funding opportunities to support academic and clinical investigators to pursue relevant topics to single ventricle heart disease. Our programs aim to foster outstanding science across disciplines, fields, and career stages — and provide resources for our awardees to succeed.

Research Programs

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Single Ventricle Research Fund (SVRF)

The Single Ventricle Research Fund (SVRF) is an annual research award program that is solely focused on accelerating research and improving care for those with single ventricle heart defects through multi-year, high-impact grants. The SVRF grants awards annually to support research projects over up to three-year periods, and provides up to $600,000 in direct costs.

In its third cycle, the SVRF is hosting an open call, and welcomes any research with relevance to single ventricle. Resubmissions from previous cycles will also be accepted.

Award Amount

Up to $600,000 in direct costs to be utilized over three (3) years

Eligibility

Principal Investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates)

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Expansion Award

Our Expansion Award enables teams to add new single ventricle focused approaches and directions to their current work — even ones that weren’t around when their study began — by providing a one-time grant of $50,000. This small but mighty grant has a submission and award process that occurs in under two months’ time, spring-boarding these studies forward, faster.

Award Amount

Up to $50,000 for one year

Eligibility

Principal Investigator(s) (PIs) who hold doctoral degrees (e.g., PhD, MD, PsyD, or equivalent) and are listed as a PI on a single-ventricle-related grant

Learn More

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Catalyst to Independence Award

Support for the next generation of scientists means investment in the future of the field.

The Additional Ventures Catalyst to Independence Award is a transition award that supports the next generation of researchers, catalyzing their careers and efforts to solve the biggest questions in single ventricle heart disease and related fields.

Award Amount

Up to $1.2M over up to 6 years

Eligibility

Applicants must have earned a PhD, MD, or doctoral equivalent more than 3 years prior to the application due date.

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Life Sciences Research Foundation: Postdoctoral Fellowship

We believe in supporting the next generation of scientists. We partner with the Life Sciences Research Foundation to support outstanding postdoctoral fellows who are making waves in basic science and advancing fundamental knowledge. Interested fellows should apply through the LSRF website.

Award Amount

$67,000 per fellow per year for three (3) years

Eligibility

Applicants must apply within 5 years of receiving their PhD or MD degree

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Funded Studies

Since 2020, we have committed over $23.5M in direct research support through our award programs. Our grant programs are changing the game by making big and bold investments in specific research questions. They are thoughtfully designed to reimagine the future by reexamining processes to maximize our impact on both people and projects.

Program
Topic
ACTION 2020

ACTION: Advanced Cardiac Therapies Improving Outcomes Network

Investigator Angie Lorts

Organization ACTION

Focus Area Data & Analytics Infrastructure

Strategic Topic Harmonized Data & Analytics Platform

Enduring Hearts 2020

Back to the Future: Expanding Opportunities in Pediatric ABO-Incompatible Heart Transplantation

Investigator Lori West

Organization University of Alberta

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Enduring Hearts 2020

Ex situ heart perfusion for optimization of pediatric donor organ utilization: feasibility and methods

Investigator Darren Freed, Jennifer Conway

Organization Stollery Children's Hospital, University of Alberta

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Enduring Hearts 2020

Novel Approaches to Improve the Availability and/or the Quality of Pediatric Donor Hearts

Investigator James Reynolds

Organization Case Western Reserve University and University Hospitals

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Enduring Hearts 2021

Can HLA data be used to support Precision Medicine in Pediatric Heart Transplantation? An exploratory analysis

Investigator David Rosenthal

Organization Stanford University

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

Enduring Hearts 2021

The impact of Fontan circulatory failure, frailty, and resilience on heart failure and transplant outcomes

Investigator Kurt Schumacher, Melissa Cousino

Organization University of Michigan

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

Expansion Award 2021

Single-cell multi-omic profiling of the developing heart to map the regulatory wiring and identify the genetic etiology of single ventricle defects

Investigator Jesse Engreitz

Organization Stanford University

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Expanded nucleotide sequencing for phenotypic mapping of cardiogenic neighborhoods 

Investigator Jonathan Butcher

Organization Cornell University

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Gene-environment interactions and single ventricle congenital heart disease

Investigator Duncan Sparrow

Organization University of Oxford

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Role of inflammation and flow in pulmonary arteriovenous malformations

Investigator Andrew Spearman

Organization The Medical College of Wisconsin

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

Expansion Award 2022

Proteomics Analyses of Proteasome Factors in Zebrafish Heart Development 

Investigator Lisa Maves

Organization Seattle Children’s Hospital

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Deep Learning and Physics Informed Neural Networks to Advance Single Ventricle Atrioventricular Valve Modeling

Investigator Matthew Jolley

Organization Children’s Hospital of Philadelphia

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

Expansion Award 2022

Spatial Transcriptomics Investigation of Pediatric HLHS Myocardium

Investigator Diwakar Turaga

Organization Texas Children’s Hospital

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Precision Therapy for Endocardial Fibroelastosis 

Investigator Ingeborg Friehs

Organization Boston Children’s Hospital

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

Expansion Award 2022

Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics

Investigator Jian Shu

Organization Massachusetts General Hospital

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Defining cell specific roles of RBFOX2 in cardiovascular development and HLHS

Investigator Muge Kuyumcu-Martinez

Organization University of Texas Medical Branch at Galveston

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2022

Predicting Cardiac Dysfunction and Fontan Failure in Single Ventricle Patients 

Investigator Andrew McCulloch

Organization University of California, San Diego

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

Expansion Award 2021

Combination proteomic and metabolic fingerprinting: a multi-omic approach to understanding longitudinal pulmonary vascular development in patients with single ventricle heart disease

Investigator Benjamin Frank, Jesse Davidson, & Michael DiMaria

Organization University of Colorado Denver/Children’s Hospital Colorado

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

Expansion Award 2021

Deciphering the splicing code in cardiac progenitor cells

Investigator Susan Liao, Oded Regev

Organization New York University

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Expansion Award 2021

A pilot biorepository of patient-specific induced pluripotent stem cells for studying pulmonary atresia with intact ventricular septum

Investigator Mingtao Zhao, Vidu Garg, Karen Texter

Organization Nationwide Children's Hospital

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

Expansion Award 2021

Characterization of exercise induced cardiac alterations in the Fontan Fitness Intervention Trial using cardiac MRI (F-FIT MRI Substudy)

Investigator Rachael Cordina

Organization University of Sydney

Focus Area Clinical Sequelae

Strategic Topic Alternative Interventions

Expansion Award 2021

Optimized metabolic biomarker detection for the development of heart failure diagnostic in single ventricle patients

Investigator Ronald Mark Payne, Thomas O'Connell

Organization Indiana University School of Medicine

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

Expansion Award 2021

Expanding the FORCE: Novel 3D Echocardiogram-Based Analysis of Ventricular Function in Single Ventricle Fontan Patients

Investigator David Harrild, Rahul Rathod

Organization Boston Children's Hospital

Focus Area Data & Analytics Infrastructure

Strategic Topic Longitudinal Clinical & Imaging Data

Expansion Award 2021

Novel Neuroimaging based Machine Learning Applications for Risk Stratification of Neurocognitive Deficits in HLHS Patients

Investigator Ashok Panigrahy, Rafael Ceschin

Organization University of Pittsburgh

Focus Area Data & Analytics Infrastructure

Strategic Topic Longitudinal Clinical & Imaging Data

Expansion Award 2021

“Single Ventricle Circulation”: Advancing a clinical decision support tool for single ventricle management

Investigator Richard Figliola, Tain-Yen Hsia

Organization Clemson University, Arnold Palmer Hospital for Children

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

Expansion Award 2021

Analysis of Cellular Metabolic Function in Single Ventricle Heart Disease

Investigator Anastacia Garcia, Shelley Miyamoto

Organization University of Colorado Anschutz Medical Campus

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

Fontan Outcomes Network (FON) 2020

FON: Fontan Outcomes Network

Investigator Jack Rychik and Sasha Opotowsky

Organization FON

Focus Area Data & Analytics Infrastructure

Strategic Topic Longitudinal Clinical & Imaging Data

FORCE 2020

FORCE: Fontan Outcomes Registry using CMR Examinations

Investigator Rahul Rathod

Organization Boston Children's Hospital

Focus Area Data & Analytics Infrastructure

Strategic Topic Longitudinal Clinical & Imaging Data

Innovation Funds 2020

Elucidating mechanisms of ventricular hypoplasia in pulmonary atresia with intact ventricular septum (PA-IVS) using patient-derived induced pluripotent stem cells (iPSCs)

Investigator Mingtao Zhao, Vidu Garg

Organization Nationwide Children's Hospital

Focus Area Disease Etiology

Strategic Topic Model Organism Development

Innovation Funds 2020

Uncovering the etiology of hypoplastic left heart syndrome using a novel frog model

Investigator Shuyi Nie

Organization Coulter BME

Focus Area Disease Etiology

Strategic Topic Model Organism Development

Innovation Funds 2020

Mapping the regulatory wiring of heart development to identify the genetic etiology of single ventricle defects

Investigator Jesse Engreitz

Organization Stanford

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

Innovation Funds 2020

Unlocking our Regenerative Capacity: Elucidating the Role of LYST on Neotissue Formation in Tissue Engineered Constructs

Investigator Richard Wilson, Christopher Breuer

Organization Nationwide Children's Hospital

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

Innovation Funds 2020

Ventricle chamber formation in mouse models of SV

Investigator Benoit Bruneau

Organization Gladstone Institutes

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

Innovation Funds 2020

In-utero Left Ventricular Filling & Its Impact on Chamber Growth and Maturation: mechanistic insights into pathogenesis of HLHS and physiological basis for fetal interventions

Investigator Muralidhar Padala

Organization Coulter BME

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

Innovation Funds 2020

Using Audio Characteristics of Systemic to Pulmonary Connections in Functionally Single-Ventricle Infants as a Non-invasive Measure of Pulmonary Blood-flow Parameters

Investigator Saidie Rodriguez

Organization Coulter BME

Focus Area Biology of Outcomes

Strategic Topic Early Detection

Innovation Funds 2020

Development of a protocol to risk stratify individuals with single ventricle congenital heart disease using deep phenotyping and genome sequencing

Investigator Kim McBride, Peter White

Organization Nationwide Children's Hospital

Focus Area Clinical Sequelae

Strategic Topic Personalized Medicine Approaches

Innovation Funds 2020

Development of a tissue engineered trans-catheter heart valve for use in the endovascular repair of single ventricle cardiac anomalies in utero

Investigator Lakshmi Prasad Dasi

Organization Coulter BME

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Innovation Funds 2020

A 3D Printed Vascularized Cardiac Biopump to Assist the Fontan Circulation

Investigator Mark Skylar-Scott

Organization Stanford

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Innovation Funds 2020

Reprogramming of Right Ventricle Cardiomyocytes to be Left Ventricular-lIke

Investigator Deepak Srivastava, Katie Pollard

Organization Gladstone Institutes

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Innovation Funds 2020

Device for Mechanically Induced Ventricular Growth in Single Ventricle Patients

Investigator Alison Marsden

Organization Stanford

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

Innovation Funds 2020

Machine Learning-Based Boundary Conditions for Fontan Surgical Planning

Investigator David Frakes

Organization Coulter BME

Focus Area Clinical Sequelae

Strategic Topic Personalized Medicine Approaches

Innovation Funds 2020

Lymphatic failure and genetic susceptibility; role in end-organ dysfunction in single ventricle patients

Investigator Yoav Dori, Daniel Licht, Hakon Hakonarson

Organization Children's Hospital of Philadelphia

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

Innovation Funds 2020

Origins and Burden of Multi-Organ Fibrosis in Patients with Single Ventricle Heart Disease

Investigator Elizabeth Goldmuntz, Jack Rychik

Organization Children's Hospital of Philadelphia

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

LSRF 2020

Deciphering the Embryonic Stem Cell Splicing Code

Investigator Susan Liao

Organization NYU Courant Institute of Mathematical Sciences

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

LSRF 2021

Engineering a self-deliverable CRISPR-Cas9 system for precise genome editing

Investigator Kai Chen

Organization University of California, Berkeley

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2020

Cerebral Lower Limit of Autoregulation Targeted Mean Arterial Pressure Management in Neonates Undergoing Surgery for Single Ventricle Congenital Heart Disease

Investigator Bradley Marino, Kenneth Brady

Organization Ann & Robert H. Lurie Children’s Hospital of Chicago

Focus Area Clinical Sequelae

Strategic Topic Alternative Interventions

SVRF 2020

Precision Therapy for Endocardial Fibroelastosis

Investigator Lili Zhang

Organization Boston Children's Hospital

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

SVRF 2020

Cerebrovascular Integrity in Fontan Patients

Investigator John Wood

Organization Children's Hospital of Los Angeles

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

SVRF 2020

Blood Viscosity, a Critical Determinant of Pulmonary Vascular Resistance in the Fontan Circulation

Investigator Jon A. Detterich

Organization Children's Hospital of Los Angeles

Focus Area Clinical Sequelae

Strategic Topic Alternative Interventions

SVRF 2020

Transforming Mental Health Outcomes in Single Ventricle Heart Disease

Investigator Nadine Kasparian, James Cnota

Organization Cincinnati Children’s Hospital

Focus Area Clinical Sequelae

Strategic Topic Alternative Interventions

SVRF 2020

Enhanced External Counterpulsation in Patients with Fontan Circulation

Investigator Fred Wu

Organization Harvard Medical School

Focus Area Clinical Sequelae

Strategic Topic Alternative Interventions

SVRF 2020

Clinical Prediction Tool for Neurodevelopmental Outcome in Single Ventricle Heart Disease

Investigator Caitlin Rollins, Cynthia Ortinau

Organization Harvard Medical School, Washington University in St. Louis Medical School

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

SVRF 2020

Development of a metabolic biomarker panel to identify SV patients at risk for heart failure

Investigator Ronald Mark Payne, Thomas O'Connell

Organization Indiana University School of Medicine

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

SVRF 2020

Nitric Oxide Pathway Biomarkers to Assess Prognosis and Individualize Care in Fontan Patients

Investigator Ari Cedars

Organization Johns Hopkins University

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

SVRF 2020

The Injection-Jet Powered Fontan Circulation: A Novel Bridge and Destination Therapy for the Failing Fontan

Investigator William DeCampli

Organization University of Central Florida

Focus Area Functional Cures

Strategic Topic Bionic, Regenerative, & Transplantation Approaches

SVRF 2021

Hippo/YAP signaling and genetic networks of HLHS​

Investigator James Martin

Organization Baylor College of Medicine

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2021

Transcriptional and morphogenetic signatures of congenital heart disease pathways

Investigator Alessandro Bertero

Organization Molecular Biotechnology Center, University of Turin

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2021

Modeling human heart morphogenesis and congenital heart disease with bioreactor-derived cardiac organoids

Investigator William Pu

Organization Boston Children's Hospital

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Embryological origin of functional single ventricles in the heterotaxy syndrome​

Investigator Sigolene Meilhac

Organization Institut Pasteur and Université de Paris

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2021

Gene-regulatory impact of Wnt signaling in ventricle formation

Investigator Christian Mosimann

Organization University of Colorado School of Medicine, Anschutz Medical Campus

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Origin of Cardiac Pacemaker Cells

Investigator Vasanth Vedantham

Organization Cardiology Division and Cardiovascular Research Institute, University of California, San Francisco

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Mechanisms of Left Ventricle Heart Development

Investigator Neil Chi

Organization University of California, San Diego

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Defining cell-specific roles of Rbfox2 in cardiovascular development​

Investigator Muge Kuyumcu-Martinez

Organization University of Texas Medical Branch

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Mechanisms of Early Ventricular Lineage Specification

Investigator Nicole Dubois

Organization Icahn School of Medicine at Mount Sinai

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Mechanobiological mechanisms of cardiac morphogenesis

Investigator Stephanie Lindsey

Organization University of California, San Diego

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Mitochondrial citrate transport: A novel, potentially druggable link to hypoplastic right heart syndrome

Investigator Jennifer Kwong

Organization Emory University School of Medicine

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

SVRF 2021

Leveraging induced pluripotent stem cells to define the developmental drivers of hypoplastic left heart syndrome

Investigator Andrew Landstrom

Organization Duke University School of Medicine

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2021

Collective Neighborhood Signaling Driving Ventricular Growth, Maturation, and Pathogenesis​

Investigator Jonathan Butcher

Organization Cornell University

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Gene-environment interactions and single ventricle congenital heart disease

Investigator Duncan Sparrow

Organization University of Oxford

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2021

Spatiotemporal decoding of the placenta-heart axis through single-cell multi-omics and spatial genomics

Investigator Jian Shu

Organization Massachusetts General Hospital

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

Defining Novel Roles for Proteasome Factors in Heart Development​

Investigator Lisa Maves

Organization Seattle Children's Research Institute

Focus Area Disease Etiology

Strategic Topic Normal Cardiac Development

SVRF 2021

A reference map of enhancers during human fetal heart development to understand the genetic etiology of single ventricle diseases

Investigator Jesse Engreitz

Organization Stanford University

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

SVRF 2020

A Multifaceted Approach to Understanding and Optimizing Single Ventricle Hemodynamics; Leveraging the Combined Power of In vitro Simulators, Computational Modeling and Clinical Imaging to Develop Non-Invasive Biomechanical Interventions.

Investigator Ellen Roche

Organization Massachusetts Institute of Technology

Focus Area Biology of Outcomes

Strategic Topic Predictive Models

SVRF 2020

Maternal Blood Biomarker Discovery for Predicting Ventricular Growth in Human Fetuses with PA-IVS

Investigator Mingtao Zhao

Organization Nationwide Children's Hospital

Focus Area Biology of Outcomes

Strategic Topic Early Detection

SVRF 2020

A Liquid Biopsy of myocardial signaling in children with single ventricle heart failure

Investigator Sushma Reddy

Organization Stanford University

Focus Area Biology of Outcomes

Strategic Topic Early Detection

SVRF 2020

Targeting mitochondrial dysfunction to prevent heart failure in single ventricle congenital heart disease

Investigator Sharon Paige, Sean Wu, Tahmina Samad

Organization Stanford University School of Medicine

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

SVRF 2020

Immunophenotyping in Pediatric Patients with Single Ventricle Congenital Heart Disease: Connecting Inflammatory and Immune Dysregulation with Outcomes

Investigator Stephanie Nakano

Organization University of Colorado Anschutz Medical Campus

Focus Area Biology of Outcomes

Strategic Topic Early Detection

SVRF 2020

Peripheral Mononuclear Cells as Biomarkers for Myocardial Metabolic Function in Single Ventricle Congenital Heart Disease Patients

Investigator Anastacia Garcia

Organization University of Colorado Anschutz Medical Campus

Focus Area Clinical Sequelae

Strategic Topic End Organ Trajectory Mapping & Biomarkers

SVRF 2020

Understanding and Reducing Sequelae Associated with Single Ventricle Physiology

Investigator Jay Humphrey, Edward Manning

Organization Yale University

Focus Area Biology of Outcomes

Strategic Topic Substrate-Outcome Relationships

SVRF Career Development Award 2021

Functional Characterization of Patient-Specific Pathogenic Variants in Single Ventricle Congenital Heart Disease

Investigator Daniel Quiat

Organization Boston Children's Hospital

Focus Area Biology of Outcomes

Strategic Topic Outcome Origins

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