For Researchers
Our approach to research funding keeps single ventricle at its heart, with a sharp focus on single ventricle defects, biomarkers, sequelae, and related comorbidities.
Extraordinary leaps in science happen when the right people, ideas, and technology come together to solve complex problems. Our goal is to facilitate these connections, innovating along with a scientific community committed to solving single ventricle heart disease.
Through our programs, we aim to cultivate and accelerate outstanding science by developing foundational knowledge, building essential infrastructure and tools, and driving innovation in interventional approaches — all while working with our community and beyond.
Research Roadmap
The 2026 Research Roadmap outlines Additional Ventures’ next chapter of investment in single ventricle research: a coordinated strategy to move the field beyond incremental progress and toward a curative standard of care.
Centered on a repair strategy, the roadmap identifies two interconnected domains — adding back pump function and addressing the systemic consequences of single ventricle physiology — supported by a deeper understanding of patient biology.
Research Award Programs
Funding outstanding research begins with a focus on people and projects. We offer funding opportunities to support academic and clinical investigators pursuing answers to critical scientific questions relevant to single ventricle heart disease. Our programs aim to foster outstanding science across disciplines, fields, and career stages — and provide resources for our awardees to succeed.
Program Spotlight
Cures Collaborative
The Additional Ventures Cures Collaborative is a multidisciplinary team of nine investigators across eight institutions brought together to develop a regenerative medicine solution that creates cardiac function with a better risk-benefit profile than is currently achieved, for both the post-natal and post-Fontan single ventricle population.
Single Ventricle SOURCE
SOURCE is the largest study of its kind, combining genomic, clinical, and family-based data to address the biggest unanswered questions in single ventricle heart disease. Our deidentified dataset, reSOURCE, is available to qualified researchers at no cost – enabling more ambitious discovery into disease mechanisms, outcomes, and new treatments.
Scientific Community
Our Speaker Series and biannual Single Ventricle Investigator Meeting allow for diverse investigators to share knowledge, identify challenges, and exchange ideas to inspire innovative approaches to this complex disease.
