Single Ventricle Research Fund (SVRF)

The Single Ventricle Research Fund (SVRF) is an annual research award program that supports foundational research to improve our mechanistic understanding of single ventricle congenital heart disease through multi-year, high-impact grants. This year, the SVRF will consider applications to both the Independent Investigator and Career Development Tracks, providing up to $600,000 and $300,000, respectively, to support direct costs over a three-year award period.

In its fifth cycle, the SVRF is hosting an open call, and welcomes any research with relevance to single ventricle. Resubmissions from previous cycles will also be accepted.

Who Fits

Proposed projects must be led by principal investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates). Proposals are accepted for two program tracks: Independent Investigator and Career Development.

Independent Investigator Track: Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status). Collaborative proposals (e.g., includes multiple lead investigators who make significant contributions) are encouraged. One principal investigator must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five (5) co-investigators may be added to each project, and they must meet the same eligibility requirements as the principal investigator.

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

What Fits

The SVRF supports foundational research efforts aimed at advancing our mechanistic understanding of single ventricle heart disease and its sequelae. We have developed a Research Roadmap in partnership with investigators across disciplines that identifies strategic solutions to address these gaps and challenges, which is intended to guide a decade’s worth of research efforts and serve as a framework for coordinating global resources to advance SV research and clinical care.

The 2024 SVRF welcomes research efforts relevant to single ventricle heart disease and aligned with any specific focus areas and areas of strategic investment in the Additional Ventures Research Roadmap, including genetics, basic cardiovascular development, tissue engineering, fetal and maternal health, computational modeling, and other relevant areas.

If your team has a compelling topic to propose that is not currently represented in the Research Roadmap, we encourage you to contact our team and submit an LOI. Submitted proposals may span multiple areas of interest.

Deadlines are subject to change at the discretion of Additional Ventures in response to nationally or globally related events, including the COVID-19 pandemic.

Previous SVRF Cycles:

The SVRF has previously focused its funding cycles in specific areas, including biomarkers & non-invasive interventions (2021) and basic cardiovascular development (2022). In it’s third (2023) and fourth (2024) cycles, the SVRF hosted an open call, accepting all proposals relevant to SV. Historically, award cycles have selected 14-17 proposals each year and have collectively awarded almost $40M to support SV research. View our list of funded studies for additional information on our SVRF awardees.

Award Amount

Up to $600,000 in direct costs to be utilized over (3) years for independent investigator track awards. Career Development track awards are eligible for up to $300,000 in direct costs.

Deadlines

Letters of intent due:

November 21, 2024

Full proposal invitations:

By December 12, 2024

Full proposal due (invite only):

February 12, 2025

Awardees announced:

By June 1, 2025

Anticipated funding:

July 1, 2025