Session Description: Individuals with single-ventricle physiology (SVP) now are showing significantly increased longevity with increased risks to brain health across lifespan. Factors that may contribute to neurodevelopmental and neurocognitive outcomes include: (a) genetic factors, (b) brain dysmaturation beginning in utero, (c) social and environmental factors, including early adversity, (d) acquired brain injury, and (e) medical complications related to SVP, such as arrhythmias, heart failure, and other issues which may develop over time. This session will feature two focused presentations and a moderated discussion about contemporary topics related to brain health, including: (1) associations between brain imaging findings, genetics, and neurodevelopmental and mental health outcomes; (2) neuroinformatic topics related to data-mining and harmonization to foster data sharing and leveraging existing consortia and registries; (3) social determinants of brain health among SVP patients across the lifespan and implications for research design and execution. 

Presenters:

Kathie Eagleson, PhD, Children’s Hospital Los Angeles

Sarah Morton, MD, PhD, Boston Children’s Hospital

Panelists:

Kathie Eagleson, PhD, Children’s Hospital Los Angeles

Nadine Kasparian, PhD, Cincinnati Children’s Hospital 

Sarah Morton, MD, PhD, Boston Children’s Hospital

Ashok Panigrahy, MD, Children’s Hospital of Pittsburgh

Caitlin Rollins, MD, Boston Children’s Hospital