Open Now! Single Ventricle Research Fund
August 12, 2025
The sixth cycle of the Single Ventricle Research Fund (SVRF), Additional Ventures’ flagship research award program, is now open!
Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment and accelerate progress toward better, more predictive, and preventative care.
The SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease. All proposals must clearly demonstrate how their aims — including any work on the origins or pathobiology of single ventricle heart disease — relate to the mechanisms driving long-term morbidity and mortality. Studies that examine cardiac development or the causes of single ventricle malformations without clear links to patient outcomes will not be considered.
Priority outcomes include preventing or reversing key organ-level complications such as lymphatic dysfunction, liver disease, impaired kidney and gut perfusion, heart failure, valve dysfunction, arrhythmia, and neurodevelopmental challenges.
While these priority areas reflect the most pressing outcome-related challenges in single ventricle heart disease, the SVRF remains open to bold, innovative outcome-related proposals that may emerge outside of these focus areas. Applications that introduce novel concepts or unexpected avenues for improving outcomes are encouraged, provided they maintain clear relevance to the long-term health and quality of life of individuals with single ventricle heart defects.
Applicants may apply for either the Independent Investigator or Career Development tracks. The Independent Investigator Track is open to both tenure and non-tenure track independent investigators, including instructors, assistant professors, and tenured faculty. The Career Development Track is open to postdoctoral fellows or postdoc equivalents who hold mentored positions. Independent Investigator track applicants can apply for up to $600,000 in direct costs, and Career Development track applicants may apply for up to $300,000 in direct costs. Indirect costs up to 10% will be provided in addition to the total funded amount.
Letters of intent for SVRF 2026 are due October 8, 2025.