Who Fits

Proposed projects must be led by principal investigator(s) who hold doctoral degrees (e.g. PhD, MD, PsyD, or equivalent doctorates). Proposals are accepted for two program tracks: Independent Investigator and Career Development.

Independent Investigator Track: Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status). Collaborative proposals (e.g., includes multiple lead investigators who make significant contributions) are encouraged. One principal investigator must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five (5) co-investigators may be added to each project, and they must meet the same eligibility requirements as the principal investigator.

Career Development Track: Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

What Fits

The SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease. All proposals must clearly demonstrate how their aims — including any work on the origins or pathobiology of single ventricle heart disease — relate to the mechanisms driving long-term morbidity and mortality. Studies that examine cardiac development or the causes of single ventricle malformations without clear links to patient outcomes will not be considered.

Priority outcomes include preventing or reversing key organ-level complications such as lymphatic dysfunction, liver disease, impaired kidney and gut perfusion, heart failure, valve dysfunction, arrhythmia, and neurodevelopmental challenges.

While these priority areas reflect the most pressing outcome-related challenges in single ventricle heart disease, the SVRF remains open to bold, innovative outcome-related proposals that may emerge outside of these focus areas. Applications that introduce novel concepts or unexpected avenues for improving outcomes are encouraged, provided they maintain clear relevance to the long-term health and quality of life of individuals with single ventricle heart defects.

Deadlines are subject to change at the discretion of Additional Ventures in response to nationally or globally related events.

Previous SVRF Cycles

Historically, the SVRF has selected 14-17 proposals each year and has collectively awarded almost $48M to support SV research. View our list of funded studies for additional information on our SVRF awardees.

Award Amount

Up to $600,000 in direct costs for the Independent Investigator Track awards. The Career Development Track awards are eligible for up to $300,000 in direct costs. Awards under both tracks span over three (3) years. Indirect costs up to 10% will be provided in addition to the total funded amount.